- An earthquake and fire destroy San Francisco on April 18. 530 died and $350 million worth of damage was done.
- Susan B. Anthony and painter Paul Cezanne died.
- President Theodore Roosevelt designated Devil's Tower, in Crook County, Wyoming, as the nation's first National Monument.
- 900 Athletes from 20 countries went to the Olympics in Athens, Greece.The U.S.A. dominated the Track and Field, taking 11 of 21 events.
- Reginald Fessenden invented the wireless telephony, a means for radio waves to carry signals a significant distance.
- The Pure Food and Drug Act forbids the marketing of any food containing "any added poisonous or deterious substance which may render it injurious to health".
- The 1906 Ford Model N, America's most popular car, sold for $500.
- Atlanta, GA experienced a race riot which required 1,000 state troopers to be stationed in the city.
- Britain took the Sinai.
- The Chicago White Sox defeated the Chicago Cubs in the World Series.
- Rudyard Kipling won the Nobel Prize in Literature
- Oklahoma became the 46th state.
- Louis Lumiere invents color photography.
- Katharine Hepburn was born.
- Ben Hur was the year's most popular movie.
- A financial panic and depression begins on March 13.
- The Hague Conference extended the rules of war and international arbitration procedures.
- A young pitcher named Walter Johnson is the sensation of the Idaho league. Clarence Darrow and members of the national press covering the Haywood trial flock to his games.